eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 447 457 10.13005/bpj/3099 65133 article Rahmi Annisa 1 Department of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia. Spanlastic is an innovative drug delivery system that traps drugs in a core cavity with a double-layer structure. The term spanlastic comes from the combination of Span and elastic, first introduced in 2011. This plastic is a development of liposomes and niosomes that have been modified sophisticatedly; several types of spanlastic include Multi Lamellar Vesicles (MLV) with a bilayer structure, size 0.5-1.0 microns, easy to make, frequently used, and long-term stable. Large Unilamellar Vesicles (LUV) measuring 100 nm-1 μm have a high water or lipid ratio and can accommodate more drugs; Small Unilamellar Vesicles (SUV) measuring 20 nm-50 μm, prepared from MLV by sonication. The growing interest in spanlastics for various administrative strategies has been evident. These nanovesicles, composed of a surfactant, are highly elastic and adaptable, encapsulating an aqueous solute solution. Studies have shown that spanlastics exhibit greater chemical stability and address several limitations of conventional dosage forms. They enhance drug delivery by enabling targeted distribution and controlled release of natural medicinal components, among other advantages. Spanlastics overcome many challenges associated with traditional drug formulations by facilitating the precise delivery of active pharmaceutical ingredients and regulating their release rate. This review highlights their significance, penetration mechanism, preparation methods, and applications. https://biomedpharmajournal.org/vol18no1/spanlastic-as-a-transdermal-drug-delivery-system-a-systematic-review/ Edge Activators Nanocarrier Nanovesicles Penetration Spanlastics Transdermal