eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 387 400 10.13005/bpj/3095 65043 article Wael Abu Dayyih 1 Shahed Amran Alsulman 1 Shahed Qassim Albtoush 1 Omar Alasasfeh 1 Department Of Pharmaceutical Sciences, Mutah University, Al Karak, Jordan LPHNPs are one of the most important applications in nanotechnology for many broad fields in pharmacy, medicine and diagnostics. In recent years, with the spread of the Covid-19 pandemic, they have been used in DNA vaccines. The reason behind this widespread use is their distinctive structure, which consists of a lipid monolayer surrounding the polymeric core. Moreover, their many types have contributed to the efficient delivery of active substances. Despite all this, there are challenges faced when dealing with LPHNPs, including the great need for tight control over the concentration of variables, the challenges of clinical transport of LPHNPs, and the challenges of instability due to storage. In this review, we discuss in a comprehensive analytical manner the general structure and types of LPHNPs, the most common methods of their preparation, the latest developments in these carriers, and provide examples of applications of using LPHNPs, potential challenges, and the most important features and additions that have improved them https://biomedpharmajournal.org/vol18no1/role-of-lphnps-a-next-generation-with-a-solid-structure-distinctive-characteristics-and-a-promising-future-in-the-medical-fields-an-updated-review/ DDS Hybrid LPHNPs   Lipid LPNs Nanoparticles Nanotechnology Next Generation Polymer Solid Structure