eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 1043 1049 10.13005/bpj/3152 65190 article Tareq Maqlam 1 Abdullah H Maad 3 Farid Ali Bagail 2 Anwar Mohsen Alhaj 2 Supreme Board of Drugs and Medical Appliances, Yemen College of Medicine and Health Sciences, Hadhramout University, Hadhramout, Yemen Department of Pharmaceutics, College of Pharmacy, University of Al-Ameed, Karbala, Iraq Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, Hodeidah, Yemen The improper use of antimicrobial agents is a major contributor to antibiotic resistance. Therefore, the initial step in addressing this issue is to assess the appropriateness of antibiotic use through drug utilization evaluation, a fundamental approach for ensuring proper medication use. This study aimed to assess the utilization of ceftriaxone in the wards of Ibn Sina Hospital. A retrospective cross-sectional study was conducted by reviewing the treatment records of 323 patients who received ceftriaxone during hospitalization between January 1 and December 31, 2017. Patient records were selected using a multistage random sampling method. Data were analyzed based on World Health Organization (WHO) criteria, which included indication, dosage, frequency, and treatment duration. Any deviation from these standards was classified as inappropriate use. The study found that ceftriaxone was administered to 44.48%, with males accounting for the majority of cases (69.4%). Overall inappropriate use of ceftriaxone was observed in 293 cases (90.8%). Misuse was more prevalent in surgical wards (98.4%) compared to medical wards (80.1%). Among the evaluated criteria, inappropriate indication was the most common issue, accounting for 66.9% of cases, followed by incorrect treatment duration (13.9%), while errors in dosage and frequency were equally observed at 5%. This study demonstrated a high rate of inappropriate ceftriaxone use, which could contribute to the development of resistant pathogens and ultimately result in treatment failure. Therefore, it is essential for prescribers to follow current evidence-based guidelines to ensure the rational use of antibiotics. https://biomedpharmajournal.org/vol18no1/evaluation-of-ceftriaxone-utilization-and-prescribing-patterns-at-ibn-sina-general-hospital-yemen/ Ceftriaxone Utilization Drug Use Evaluation Ibn Sina General Hospital Inappropriate Prescribing Yemen