eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 593 603 10.13005/bpj/3111 63630 article Rupachandra Saravanakumar 1 Dharshene Karthik 1 Raj Kumar 1 Lavanya Mohan 1 Rabeela 1 Nithesh Jerome 1 Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, India The inadequacy of eliminating the entire population of tumor cell and the concomitant creation of chemoresistance is a major challenge for an effective colon cancer treatment. Many compounds which are natural have been shown to be optimistic, based upon their antitumor effects and a decrease in toxicity. Natural cyclopeptides are small peptides that are rich in disulfide bonds having a cyclic backbone being isolated from plants. The peptides are resistant to enzymatic, thermal and chemical conditions due to the presence of the cyclic cystine knot like structure. Plant derived cyclic peptides hold a very significant role in the field of cancer chemotherapy. However, a never-ending endeavor is a search to find novel therapeutic compounds for treating and controlling cancer. RA-V (deoxybouvardin), is a natural cyclopeptide that is extracted from the Bouvardia ternifolia roots belonging to the Rubiaceae family. RA-V cyclopeptide exhibits anti-angiogenesis, anti-inflammatory and anti-cancer activities. Apoptosis means a programmed cell death which is being characterized by membrane blebbing, nuclear fragmentation and chromosome condensation. This study focuses on evaluating the efficacy of cyclopeptide RA-V in human colon cancer cell lines. https://biomedpharmajournal.org/vol18no1/assessment-of-apoptosis-inducing-potential-of-cyclopeptide-ra-v-on-human-colo-205-colon-cancer-cells/ Apoptosis Cell death Chemotherapy Colon Cancer Cyclopeptide Rubiaceae