eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 957 963 10.13005/bpj/3144 64571 article Lalitha Surulichamy 1 Deepika Chandrasekaran 2 Anusha Dakshinamoorti 3 Department of Physiology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai Department of Physiology, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research (Deemed to be University), Kanchipuram Department of Pharmacology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai Background: The phytochemical components of most medicinal plants contain diverse pharmacological properties like antioxidant, anti-inflammatory to protect it from environmental stress and insects. In the recent years many studies are conducted to identify the therapeutic effect of such plant extracts as they can be used for treating many degenerative diseases. Cayratia auriculata(Roxb)  is a local south Indian species with many medicinal properties. Hence it becomes essential to identify its antioxidant, anti-inflammatory properties. Aim: To assess the anti-inflammatory and anti-oxidant effects of C.auriculata. Methods and materials: C.auriculata was collected in November 2018 from the Araku valley, Visakhapatnam, Andhra Pradesh, India. Preliminary phytochemical qualitative and quantitative analysis was carried out. Then in vitro DPPH radical scavenging activity, BSA Denaturation procedures were conducted to assess its anti-oxidant and anti-inflammatory actions. Results: Antioxidant Property was assessed based on the DPPH absorbance reduction indicating the free radicals scavenging action of the extract. IC50 value was obtained and calculated as 1386.207µg/mL. Anti-inflammatory property was assessed based on 1% Bovine serum albumin assay results which showed different concentrations exhibit different level of inhibition. IC50 Value was calculated and observed to be 12.564µg/mL. Conclusion: The antioxidant and anti-inflammatory property of ethanolic leaf extract of C. auriculata can serve as a reliable pharmacological therapy for many degenerative disorders caused due to chronic cellular stress and inflammations. Alternative herbal medicines from traditional sources have the potential to be an effective, affordable, and accessible remedy. https://biomedpharmajournal.org/vol18no1/antioxidant-and-anti-inflammatory-effects-of-cayratia-auriculata-roxb-a-traditional-south-indian-medicinal-plant/ Anti-inflammation Anti-oxidants Cayratia auriculata (Roxb) Herbal medicine In vitro Phytochemical analysis