eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 605 615 10.13005/bpj/3112 63666 article Rajappan Chandra Satish Kumar 1 Chittaranjan Das 1 Mothishwaran Bhuvaneshwaran 2 Kunka Mohanram Ramkumar 3 Sri Jayendra Saraswathi Ayurveda College and Hospital, Sri Chandrashekarendra Viswa Vidyalaya, Kanchipuram, 600 123, Tamil Nadu, India. Clinical Trial and Research Unit, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, 603 203, Tamil Nadu, India Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India Diabetes mellitus is a chronic metabolic disorder associated with high rates of morbidity and mortality globally. Ayurvedic medicine offers promising approaches for managing diabetes, with Niruryadi Gulika (NG) emerging as a potential therapeutic agent. This study evaluated the effects of NG in comparison to metformin, a widely used antidiabetic drug, in in streptozotocin (STZ)-induced diabetic rats. Experimental groups included control, diabetic control, metformin-treated and NG-treated groups, monitored over a 6-week period. Various parameters included circulating glucose levels, plasma insulin, total haemoglobin, glycosylated haemoglobin, lipid profile (cholesterol, triglyceride, HDL, LDL), antioxidant enzymes (catalase, GPx), and lipid peroxidation (TBARS) were assessed. Our results demonstrated that NG particularly at two doses, significantly reduced blood glucose levels, glycosylated haemoglobin, and lipid peroxidation, while enhancing plasma insulin levels, total haemoglobin, and antioxidant enzyme activity compared to diabetic control rats. NG also improved lipid profile markers, such as cholesterol and triglycerides, achieving effects comparable to metformin. Furthermore, NG treatment reduced elevated cytokine levels, including TNF-α and IL-6, in diabetic rats, reflecting the anti-inflammatory effects of metformin. These findings highlight NG’s potential as an effective anti-diabetic agent, showing promising results comparable to metformin. Further research is warranted to better understand the mechanisms of NG and optimize its dosage regimen for managing diabetes mellitus. https://biomedpharmajournal.org/vol18no1/antidiabetic-activity-of-ayurvedic-niruryadi-gulika-in-experimental-diabetes/ Antioxidants Ayurvedic drugs Diabetes Niruryadi Gulika Oxidative stress