eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 867 877 10.13005/bpj/3135 63680 article Frederick Sarfo-Antwi 1 Abdul-Rashid Lansah Adam 1 Christopher Larbie 2 Benjamin Obukowho Emikpe 3 Jennifer Suurbaar 1 Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Ghana. Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Department of Veterinary Pathology, School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Background: Kidney diseases remain a significant global health challenge, prompting researchers to explore the therapeutic potential of medicinal plants for treating various ailments, including renal disorders. This study aimed to evaluate the anti-inflammatory and antioxidant effects of the ethanolic extract of Ageratum conyzoides leaves (ESE) on kidney damage induced by carbon tetrachloride (CCl₄) in a rat model. Methods: Haematological and biochemical indicators were used to evaluate the nephroprotective efficacy. Rat kidney homogenates were used to assess antioxidant and anti-inflammatory biomarkers. The histological data was used to evaluate the amount of kidney injury. Results: Pro-inflammatory cytokine expression increases brought on by CCl₄ insult were dramatically and dose-dependently inhibited by ESE treatment. A significant reduction in lipid peroxidation of kidney tissue brought the concentration of defensive antioxidant enzymes to near-normal levels. The beneficial activities of ESE on CCl₄-induced hepatotoxicity damage were validated by histopathological analysis of the kidney; the maximum percentage of liver protection was observed when ESE was induced at a dosage of 500 mg/kg b.wt. Conclusion: According to the findings, ESE protects the kidneys against CCl₄-induced toxicity through anti-inflammatory and anti-oxidative effects. This response possibly may be due to the presence of phytochemicals. https://biomedpharmajournal.org/vol18no1/anti-inflammatory-and-antioxidant-potential-of-ageratum-conyzoides-ethanol-extract-against-carbon-tetrachloride-induced-renal-toxicity-in-rats/ Biochemical Cytokines Homogenates Kidney Peroxidation