eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-02-20 18 March Spl Edition 1 15 10.13005/bpj/3069 63993 article Yogita Ale 1 Rekha Verma 2 Nidhi Nainwal 1 Sanjeev Kumar Shah 3 Vikash Jakhmola 4 Pankaj Pant 5 Department of Pharmaceutics, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, India. Department of Management, DBS Global University, Dehradun, Uttarakhand, India. Uttaranchal Institute of Technology, Uttaranchal University, Dehradun-248007, Uttarakhand, India. Department of Pharmaceutical Chemistry, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun-248007, Uttarakhand, India. Faculty of Pharmacy, School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun-248009, Uttarakhand, India. The enactment of advanced technologies and processes accomplished by the Internet of Things (IoT), Artificial Intelligence (AI), Cloud Computing, and Big Data for development over domestic and global markets represent the new paradigm, Industry 4.0. The application of these technologies in the pharmaceutical industry and other health sector will simplify the production of complex medications, which is a major benefit of the paradigm shift. Industry 4.0 was implemented to streamline complex processes and reduce reliance on human labour. Although most pharmaceutical industries still understand the concept of Industry 3.0, it is challenging for manufacturers and regulators to cope with the current scenario and meet the guidelines and requirements of different regulatory bodies. This review article highlighted the application of IoT and other novel advanced technologies in the pharmaceutical sector. Additionally, outlined the major challenges including high-cost installations, the need for expertise and training, and regulatory enforcement. Industries and regulatory bodies are working together to develop computational engineering methodologies necessary to support and promote autonomous systems with artificial intelligence and computing infrastructures for the development of the pharmaceutical sector. https://biomedpharmajournal.org/vol18marchspledition/iot-in-revolutionizing-the-pharmaceutical-sector-applications-and-challenges/ Artificial Intelligence Cloud computing Digitalization Industrial revolutions Internet of Things