eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-12-30 17 4 2585 2592 10.13005/bpj/3050 63092 article Fazlkhan Abdugapparov 1 Lochin Mamatov 2 Dauranbek Ongarbayev 3 Department of Phthisiology and Pulmonology of the Tashkent medical academy, Republic of Uzbekistan, Tashkent region, Chirchik city, Ibn Sino Department of Phthisiology and Pulmonology of the Tashkent medical academy, Republic of Uzbekistan, Tashkent city, Mirabad district, Tallimarjon Department of Phthisiology and Pulmonology of the Tashkent medical academy, Republic of Uzbekistan, Tashkent city, Almazar district, Tansiqbayev Extrapulmonary TB, representing nearly 15% of the global TB burden, is more difficult to diagnose. Tuberculous pleural effusion (TPE), one of the commonest forms of extrapulmonary TB, is a diagnostic challenge with rather poor microbiologic confirmation rates from pleural fluid analysis^2,3. Even diagnostic tools like CBNAAT and interferon-gamma release assays have shown suboptimal diagnostic accuracy^4,5. Adenosine deaminase (ADA), an enzyme produced from lymphocytes and involved in purine metabolism, has been extensively studied as a biochemical marker in pleural fluid during investigation for TPE. The test is simple, cheap, rapid, minimally invasive, and can be performed in most laboratories³. https://biomedpharmajournal.org/vol17no4/tuberculous-pleurisy-the-role-of-the-ada-enzyme-in-diagnosis-and-treatment-outcomes/ Adenosine Deaminase Diagnostic Markers Pleural Fluid Tuberculous Pleuritis   Tuberculosis Treatment Outcomes