eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-12-30 17 4 2693 2707 10.13005/bpj/3059 62910 article Dewa Ayu Agung Alit Suka Astini1 1 I Wayan Putu Sutirta Yasa 3 I Made Jawi 4 I Nyoman Wande 3 Putu Indah Budi Apsari 5 Luh Gde Evayanti 2 Doctoral Program, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia Anatomy Departement, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Denpasar, Indonesia Clinical Pathology Department, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia Pharmacology Department, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia Parasitology Departement, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Denpasar, Indonesia Noise is an environmental condition that we encounter in everyday life. The level of noise varies in certain environments, such as work environments, traffic on highways, noise in cafeterias, and others. This exposure can affect the coordination system in our body, such as the cerebellum. Soursop leaf extract has been widely used in traditional medicine, the antioxidant content in this extract has many health benefits. Soursop leaf extract (Annona muricata L.) can be useful as an anti-inflammatory, providing protection to nerve cells from free radicals, and other benefits. This study aims to test the effect of soursop leaf extract on neurons in the cerebellum layer. The study was conducted at the experimental animal stage. The experimental animals used were adult Wistar rats which were divided into 2 control groups and 1 treatment group. Each group consisted of 15 Wistar rats. The treatment group was given ethanol extract of soursop leaves before being exposed to noise. The results showed that there were significant differences in the density of molecular layer nerve fibers, between K- and K+ groups (p=0.000) and P (p=0.015), between K+ and P groups (p=0.015). There was a significant difference in Purkinje cell degeneration in the control and treatment groups, between K- and K+ groups (p=0.000) and P (p=0.003), between K+ and P groups (p=0.015). There was no significant difference in granular cell degeneration in the control and treatment groups, between K- and K+ groups (p=0.061) and P (p=0.838), between K+ and P (p=0.094), but the degeneration was lighter in P than K+. The conclusion of this study is that soursop leaf extract provides protection to neurons in the cerebellum from noise exposure. https://biomedpharmajournal.org/vol17no4/the-effect-of-ethanolic-extract-of-annona-muricata-l-leaves-on-cerebellum-neurons-in-noise-exposed-adult-wistar-rats/ Antioxidant Granular Cells Neuroprotective Purkinje Cells Soursop Leaf