eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-12-30 17 4 2329 2339 10.13005/bpj/3028 62067 article Rahmi Annisa 1 Roihatul Muti’ah 1 Avin Ainur Fitrianingsih 2 Begum Fauziyah 1 Nabila Rahmadani 1 Wirda Anggraini 1 Departement of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim Malang, East Java, Indonesia Departement of Medicine, Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim Malang, East Java, Indonesia This study aimed to determine the release and absorption flux values of qusthul Hindi (Saussurea lappa) self nanoemulsifying drug delivery system using the template formula for the optimal D-optimal design approach. The method is emulsification. The in vitro release test used the dialysis bag method. The absorption test was carried out through the intestinal membrane using the Crane and Wilson tube method. The levels released and absorbed were measured using a UV-Vis Spectrophotometer. The results showed that in vitro release and absorption values in SNEDDS were higher than the qusthul Hindi (Saussurea lappa) extract solution in both artificial intestinal fluid media at pH 6.8 ± 0.05 and artificial gastric fluid at pH 1.2 ± 0.05. The analysis found a significant difference in flux for both release (p=0.02) and absorption (p=0.01). The SNEDDS formula provided in vitro release flux results that were 4.20 times higher in AGF media and 5.62 times higher in AIF media compared to the extract solution. In vitroabsorption results also indicated a  4.02 times increase in AGF media and 3.32 times higher in AIF compared to the extract solution. The selected formulas using miglyol 812, Tween 80, and Polyethylenflycol 400 components at concentrations of 2.13%, 5.81%, and 2.06% can be used for SNEDDS formulations of qusthul Hindi (Saussurea lappa). These formulations showed superior in vitro release and absorption results compared to the extract solution in both AIF media at pH 6.8 ± 0.05 and AGF media at pH 1.2 ± 0.05. https://biomedpharmajournal.org/vol17no4/evaluation-of-self-nanoemulsifying-drug-delivery-system-from-qusthul-hindi-saussurea-lappa-extract-in-vitro-release-and-absorption-assessment/ Absorption test Qusthul Hindi Release test Saussurea lappa  Self-nanoemulsifying