eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-12-30 17 4 2177 2186 10.13005/bpj/3015 63114 article Siti Nor Aqilah Mohd Noor 1 Umar Idris Ibrahim 1 Shazia Jamshed 2 Nurulumi Ahmad 1 Aslinda Jamil 1 Rosliza Yahaya 3 Faculty of Pharmacy, Universiti Sultan Zainal Abidin (UniSZA), Kampus Besut, Besut, Terengganu, Malaysia, 2School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, Malaysia, 3Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Kampus Perubatan, Jalan Sultan Mahmud, Kuala Terengganu, Terengganu, Malaysia Depression remains a major global health crisis, impacting millions worldwide. The swift progression of digital health technology has intensified interest in employing mobile health (mHealth) applications to tackle mental health concerns, particularly depression. mHealth applications for depression management constitute a groundbreaking method, providing globally scalable and accessible solutions that can significantly enhance mental health care. This study sought to assess the existing evidence about the utilization and effectiveness of mHealth applications in the management of depressive symptoms. Studies were identified by literature searches in three electronic databases (Scopus, Science Direct, and PubMed) from 2000 to 2024. Studies were chosen according to a set of inclusion criteria and reviewed narratively (n = 21). Research indicates that six studies investigated the prevalence of depression, whereas twelve studies emphasized the function and features of mHealth applications in symptom management. Significant enhancements in mental health outcomes were documented in seven studies (n = 7), showing the efficacy of these programs in engaging users and reducing depressive symptoms. The primary limitations of current mHealth literature are: 1) focus on screening rather than follow-up care; 2) limited accessibility; 3) insufficient user engagement; 4) small sample sizes; 5) absence of cost-effectiveness statistics; and 6) inconsistent app quality. To address these challenges, the focus must be directed toward optimal application design and enhanced accessibility. All these research gaps are crucial to be overcome for advancing evidence-based solutions and empowering the digital health sector to improve mental health outcomes for this cohort. https://biomedpharmajournal.org/vol17no4/bridging-the-gap-the-promise-and-pitfalls-of-mobile-health-apps-for-depression-management/ Depression Depression Screening Digital Health Mhealth Mobile Application