eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-12-30 17 4 2135 2145 10.13005/bpj/3012 63030 article Heru Sasongko 1 Aulia Hanundita Maharani 1 Joshua Arianto Hutasoit 1 Darmawan Lahru Riatma 2 Hardian Ningsih 3 Sritrusta Sukaridhoto 4 Department of Pharmacy, Vocational School, Sebelas Maret University, Central Java, Indonesia. Department of Informatic Engineering, Vocational School, Sebelas Maret University, Central Java, Indonesia. Department of Agribusiness, Vocational School, Sebelas Maret University, Surakarta, Central Java, Indonesia. Department of Informatic Engineering and Computer, Politeknik Elektronika Negeri Surabaya, Jl. Raya ITS, Sukolilo, Surabaya, East Java, Indonesia. Department of Informatic Engineering and Computer, Politeknik Negeri Madiun, Taman, Pandean, Madiun City, East Java, Indonesia. Department of Pharmaceutics, Faculty of Pharmacy, Universitas of Gadjah Mada, Yogyakarta, Indonesia. Turmeric (Curcuma longa) are known to contain curcumin, a lipophilic polyphenol from the curcuminoid group. Curcumin has been used for generations in traditional medicine, due to antioxidant, anti-inflammatory, hepatoprotective, cardio-protective, antimicrobial, nephroprotective, immunomodulatory, hypoglycemic, anti-rheumatic, anti-cancer, and anti-fibrotic properties. Therefore, this study aimed to determine pharmacological activity potential of curcumin using selected test parameters. Several journals were collected from PubMed, Scopus, and Science Direct for this review, limiting the time frame to the last 8 years. The findings are then presented in the form of figures and tables, followed by a full discussion based on the appropriate reference. The results showed that curcumin had antioxidant and anti-inflammatory effects. These effects contributed to various mechanisms of action in numerous diseases, including cardiovascular, anti-cancer, arthritis, brain injury, Alzheimer's, digestive disorders, anti-aging, and hepatoprotection. Several external factors that influenced test results included curcumin dosage, duration of administration, and pain- or disease-inducing ingredients. In long-term therapy with certain drugs, the administration of curcumin could be considered at the right dose to avoid dangerous side effects. https://biomedpharmajournal.org/vol17no4/an-updated-review-of-curcumin-in-health-applications-in-vivo-studies-and-clinical-trials/ Antioxidant Anti-Inflammatory Curcumin Pharmacological Activity Rhizomes