eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-09-30 17 3 1837 1845 10.13005/bpj/2989 61073 article Mustafa K. Mushatet 1 Asaad Abbas Khalaf 1 Doaa A. Hamad 1 Thikra Abd Jary 2 University of Kerbala, College of Nursing, Branch of basic sciences, Kerbala, Iraq University of Al-Ameed, College of Medicine, Branch of Biochemistry, Kerbala, Iraq This research looked at how an aquatic Eucalyptus globulus extract (ECP) affected inflammation and oxidative stress in male rats that were given an experimental form of carrageenan (CRG). The study randomly assigned twenty-four male Wistar rats. In the study, 2 ml of physiological solution was administered to the control group, 0.6 g/kg of ECP BW was given to the ECP group orally, 100 μl of the CRG solution dissolved in 1 milliliter of distilled water was injected intraperitoneally to the CRG group for 30 days, and 0.6 g/kg of BW of ECP was given orally to the C&E group for 15 days after 15 days of 100 μl of the carrageenan solution dissolved in 1 milliliter of distilled water intraperitoneal injection. We sacrificed the rats after 30 days and analyzed the serum samples to measure white blood cell count (WBC), lymphocytes, monocytes, neutrophils, C-reactive protein (CRP), and tumor necrosis factor (TNF). The study found that the CRG and C&E groups had higher levels of WBC, lymphocytes, monocytes, neutrophils, CRP, and TNF than the ECP and control groups. The decrease in inflammation markers CRP and TNF in the serum of E&C group rats demonstrates that ECP's aqueous extract has anti-inflammatory properties. However, further clinical and histological research is necessary to validate its potential as a therapeutic agent. https://biomedpharmajournal.org/vol17no3/the-effect-of-an-aquatic-extract-of-eucalyptus-globulus-leaves-on-reducing-the-inflammation-parameters-caused-by-carrageenan-in-male-wistar-rats/ Carrageenan C- Reactive Protein Eucalyptus Globulus Inflammatory Lymphocytes Monocytes Necrosis Factor Neutrophils and Tumor