eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-09-30 17 3 1347 1364 10.13005/bpj/2949 60880 article Abdel-Nasser El-Shorbagi 1 Sachin Chaudhary 1 Hitesh Kumar 3 Harish Chandra Verma 4 Prabhash Nath Tripathi 5 Aditi Giri 5 Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates Faculty of Pharmacy, University of Assiut, Assiut, Egypt Department of Pharmaceutics, RV Institute of Pharmacy, Bijnor, Uttar Pradesh, India Department of Pharmaceutical Chemistry, College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Road Crossing, Bypass Road, Meerut, Uttar Pradesh, India Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India Doxorubicin that is on WHO's list of essential medicines and other anthracycline analogues, in general, are natural metabolites isolated from Streptomycetaceae, or semi-synthetized derivatives stated as first-generation anticancer agents. The tetracyclic scaffold attached mostly to amino sugar is known to be effective against solid tumors compared to other anticancer agents. The mechanism had been stated as intercalating agent at the minor groove of DNA strands during the step of releasing supercoiled DNA. Along with their anticancer activity, anthracyclines possess antimicrobial effects of notable MIC values. Cardiotoxicity represents the main challenge for both of medical care for treatment of cancers and drug discoverers. This exertion deals with careful structural investigation of the three-dimensional, fully optimized drugs in use. Drug-candidates in clinical studies, and leads failed in last developments. The aim is to find a structural gate to guard against or reduce the cardiac side effects. It deals also, with the topological features differentiating between antibacterial and anticancer agents bearing the tetracyclic scaffold features as well as between the topoisomerases as target molecules. https://biomedpharmajournal.org/vol17no3/structural-variance-of-doxorubicin-and-anthracycline-analogues-as-topoisomerase-alpha-and-beta-top2a-and-top2b-inhibitors-potential-design-of-analogue-candidates-of-less-side-effects-on-cardiomyocy/ Anticancer Activity Anthracycline Cardiac Toxicity Doxorubicin Fully Optimized 3D Structure Gene Topoisomerase Top2A Topoisomerase Top2B