eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-09-30 17 3 1635 1645 10.13005/bpj/2971 61041 article Nagaraju Bandaru 1 Namanda Shamim 2 Siripalli Bhagaya Nagalakshmi 3 Thumalapalli Sunanda 4 Ch.Hanisha 5 Makarand Suresh Gambhire 6 School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik, Maharashtra Department of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, AP, India. Department of Pharmacology, Lydia College of Pharmacy,Ethakota, Ravulapalem, AP, India. Department of Pharmacology, Nalla Narasimha Reddy Group of Institutions, Peerzadiguda, Hyderabad, Telangana, India. Department of Pharmaceutics, School of Pharmacy, Mohanbabu University, Tirupathi, AP, India. Department of Pharmaceutical Analysis, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram. AP, India. Aim: To evaluate the Neuroprotective activity of Biophytum reinwardtii Platinum nanoparticles Methods: Biophytum reinwerdtii platinum nanoparticles were subjected to evaluation of the neuroprotection activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced zebra fishes. Experimental fishes are divided into 5 groups, each containing 8 fishes. Group I is considered a normal group; Group II is a toxic group means treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 225 mg/kg, i.p. for 5 days; Group III, IV, and V are treatment groups means treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (225 mg/kg) with 0.3 µmol, 0.4µmol, and 0.5 µmol of Biophytum reinwardtii Platinum nanoparticles respectively for 5 days. Results: In the in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine group, locomotor activity and complex I activity are decreased, Malondialdehyde levels increased, antioxidants, and catecholamines levels decreased, whereas Biophytum reinwardtii Platinum nanoparticles treated fishes exhibit significant locomotor and increased levels of antioxidants and catecholamines. Conclusion: These results suggest that Biophytum reinwardtii Platinum nanoparticles. Showed significant neuroprotection activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -induced Parkinson’s zebra fishes. https://biomedpharmajournal.org/vol17no3/preparation-of-platinum-nanoparticles-of-biophytum-reinwardtii-and-evaluation-of-neuroprotective-activity-of-mptp-induced-parkinsons-disease-in-zebra-fish/ Antioxidants Locomotor Activities 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine Nanoparticles Parkinson’s Platinum