eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-09-30 17 3 1821 1829 10.13005/bpj/2987 61156 article Radhika Chellasamy 1 Sathish Thanikodi 2 Kamesh Krishnamoorthy 3 Gnanavel Balakrishnan Kannaiyan 4 Ragavanantham Shanmugam 5 Monsuru Ramoni 6 Mechanical Department, Saveetha Engineering College, Thandalam, Chennai, Tamil Nadu, India Department of Mechanical Engineering, Saveetha School of Engineering, Chennai, Tamil Nadu, India Tool and Die Making, Murugappa Polytechnic College, Chennai, Chennai, Tamil Nadu, India Mechanical Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India Department of Engineering and Technology, Fairmont State University, West Virginia, United States of America. Industrial Engineering, Navajo Technical University, NM, United States of America. To facilitate the delivery of drugs into the skin structure, microneedles play a pivotal role. Unlike conventional hypodermic syringes, microneedles penetrate only the dermis layer, avoiding nerve receptors and resulting in a painless injection. However, when a drug is administered into the skin, microneedles may undergo bending and buckling, leading to structural failure. Such failure can cause the drug to remain beneath the skin, potentially creating complications. Preventing the catastrophe of microneedle failure necessitates a close examination of parameters involved in the bending and buckling process. In this paper, we focus on buckling analysis, as the majority of microneedle failures are attributed to the buckling effect. We perform buckling analysis through finite element analysis to predict the critical buckling load (Pcr). This analysis helps determine the maximum load that a microneedle can withstand. We conduct this analysis using two modes: linear and non-linear (post-buckling analysis). By varying the tip diameter of the microneedle (20µm, 40µm, 60µm, 80µm, 100µm), we can identify the safe insertion load. https://biomedpharmajournal.org/vol17no3/linear-and-post-buckling-analysis-of-biocompatible-polymer-microneedle-for-transdermal-drug-delivery/ Buckling analysis Critical buckling load Finite element analysis Polycarbonate microneedle post-buckling behavior