eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-09-30 17 3 1931 1936 10.13005/bpj/2995 60953 article Qubaa Ahmed Elzubair 1 Mohamed Alfaki 2 Musaab Ahmed 3 Khalid Sukar 4 Sara Mohammed 4 Sofiyat Zayyad 4 Department of Histopathology and Cytology, Alemadi Hospital, Doha, Qatar. Sidra Medicine, Doha, Qatar. Gezira Centre for Gastrointestinal Tract Endoscopy and Laparoscopic Surgery, Gezira, Sudan. College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates Department Histopathology and Cytopathology, Wad Medani College of Medical Sciences and Technology, Doha, Qatar. Department Histopathology and Cytopathology, Collage of Medical Laboratory Sciences, Wad Madani, Sudan. Introduction: Worldwide, breast cancer is the most prevalent cancer among women to be diagnosed, and it is the primary cause of cancer-related mortality, coming in second only to lung cancer. High levels of Ki67, a nuclear marker of cell proliferation, in breast cancer are linked to worse outcomes. Methods and materials: This retrospective cross-sectional laboratory investigation aimed to examine Ki67 expression as a prognostic predictor in invasive ductal carcinoma (IDC) utilizing manual tissue microarrays (MTMAs) technology. The study was done from June 2018 to July 2019 at the Elrahman Health Centre in Khartoum, Sudan, using thirty-five paraffin block samples collected from patients previously diagnosed with invasive ductal carcinoma (IDC). The study population ranged in age from 31 to 71 years. Results: The study found that 94.3% (n=33/35) of the tissues were positive for the Ki67 antigen, while 5.7% (n=2/35) were negative. Age and score correlation is (P=0.047), and a favorable prognosis could be the cause of the two unfavorable results. Conclusion: This study highlights the importance of the Ki67 biomarker as a prognostic indicator in invasive ductal carcinoma (IDC) of the breast. High levels of Ki67 expression (94.3%) were associated with more aggressive tumors and poorer prognostic outcomes. However, there was no significant correlation between Ki67 scores and patient age, indicating age does not influence the prognostic value of Ki67 in this cohort. https://biomedpharmajournal.org/vol17no3/evaluation-of-ki67-biomarker-as-a-prognostic-marker-in-breast-invasive-ductal-carcinoma-in-khartoum-state-in-sudan/ Breast cancer Invasive Ductal Carcinoma Ki-67 Tissue Microarrays