eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-09-30 17 3 1757 1767 10.13005/bpj/2981 61203 article Ramachandran Tamilselvi 1 Maniarasu Kalaiarasi 1 M. Elumalai 2 Thanthoni Malarkodi 3 Alagarswamy Venkatesh 1 Venkatachalam Prakash 1 Department of Conservative Dentistry and Endodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamilnadu, India Department of Zoology and Biotechnology, Government Arts College, Nandanam, Chennai, Tamilnadu, India 3Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamilnadu, India A broad range of gram positive and gram negative bacteria have been demonstrated to be effectively suppressed in growth by Metal Oxide Nanoparticles (MONPs), suggesting that these particles may be useful in the fight against antibiotic resistance. The antibacterial characteristics of MONPs, including those of silver, zinc, titanium, zirconia, iron, copper, magnesium, and cobalt oxide are widely recognized. The use of these nanoparticles made of synthetic and natural materials in dentistry is developing quickly, has been included in a variety of dental materials and has assisted in the treatment of oral disorders as well as the removal of biofilms and smear layers. The reader will gain up-to-date knowledge on MONPs, their modes of action, and their significance in endodontics in this review. https://biomedpharmajournal.org/vol17no3/antimicrobial-activity-of-metal-oxide-nanoparticles/ Antibacterial Drug delivery Endodontic Metal oxides Multidrug resistant Nanoparticles