eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 1213 1222 10.13005/bpj/2935 59276 article Omonturdiev Sirojiddin Zoirovich 1 Abdullaev Izzatullo Ziyoyiddin Ugli 1 Inomjonov Dolimjon Raxmatillayevich 2 Maxmudov Lazizbek Umarjonovich 1 Zaripova Mehrangiz Ravshanovna 1 Gayibova Sabina, Narimanovna 1 A. S. Sadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Republic, Uzbekistan Namangan state University Uzbekistan According to the literature, Ájuga turkestánica extract has an effective impact on diseases of the cardiovascular system. Aortic smooth muscle ion transport systems play an important role in the development of these diseases¹. This study investigated the effects of  Ájuga turkestánica extract on ion transport systems in rat aortic smooth muscle preparations under isometric conditions in vitro, and it was found that this extract exerts a strong dose-dependent relaxant effect on the contraction induced by KCl (50 mM) From the obtained results, the effect of this extract on potential-dependent Ca²⁺ channels was estimated, and in order to confirm the assumption, it was compared with verapamil, a specific blocker of this channel, and the effect of Ájuga turkestánica extract on potential-dependent Ca²⁺ channels was determined. In the course of the studies, it was assumed that the investigated extract affects not only the potential-dependent Ca²⁺ channels, but also the receptor-dependent Ca²⁺ channels, the Ca²⁺ transport system in the sarcoplasmic reticulum, and the endothelium-dependent relaxation mechanisms. According to the results of the study, it was found that Ájuga turkestánica extract has an effective effect on these ion transport systems (the results obtained are described in detail in the article below). https://biomedpharmajournal.org/vol17no2/the-effect-of-ajuga-turkestanica-on-the-rat-aortic-smooth-muscle-ion-channels/ Ájuga turkestánica Ca⁺² -ATPase IP₃R Phenylephrine Phentolamine receptor-dependent (TRP) channels Voltage-gated Ca⁺ (VGCC) channels