eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 1203 1212 10.13005/bpj/2934 59253 article Anu Altangerel 1 Chimedragchaa Chimedtseren 2 Myadagbadam Urtnasan 2 Dejidmaa Buyantogtokh 2 Dagvatseren Begzsuren 2 Zulgerel Dandii 3 International School of Mongolian Medicine, Mongolian National University of Medical Science, Ulaanbaatar, Mongolia. Institute of Traditional Medicine and Technology, Ulaanbaatar, Mongolia. School of Medicine, Mongolian National University of Medical Science, Ulaanbaatar, Mongolia. Marchin-13 Tang is a traditional Mongolian medicine widely used to reduce blood pressure. The study aimed to evaluate the anti-hypertensive effect of Marchin-13 (M-13) Tang in the L-NAME-induced model of hypertension. The biological composition activity of M-13 Tang was examined using the UV spectrophotometric method. The experimental groups induced Hypertension models by L-NAME 40 mg/kg. The concentrations of serum nitric oxide (NO), Angiotensin-Converting Enzyme (ACE), superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT) were measured in M-13 Tang treatment groups by enzyme-linked immunosorbent assay (ELISA). The content of total phenolics was measured at 2.96±0.16%, while flavonoids were found to be present at a level of 1.81±0.1%. The reductions in mean arterial pressure (MAP) were statistically significant. They were observed from day 14 to day 21 after giving M-13 Tang at 90 mg/kg and 180 mg/kg (p<0.01). Moreover, treated with M-13 Tang 90 mg/kg and 180 mg/kg groups, serum levels of NO, SOD, and CAT were significantly (p<0.01) increased compared with the L-NAME (40 mg/kg) group. The levels of MDA and ACE showed a significant decrease in both the Marchin-13 Tang-treated groups compared to the L-NAME group (p<0.05). The results of our study illustrate that Marchin-13 effectively reduced blood pressure by mitigating oxidative stress, enhancing NO production, and decreasing ACE levels in hypertensive rats induced by L-NAME. https://biomedpharmajournal.org/vol17no2/the-antihypertensive-effect-of-marchin-13-tang-on-l-name-induced-hypertension-in-rats/ Hypertensive L-NAME Marchin-13 Mongolian traditional medicine Nitric oxide