eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 627 633 10.13005/bpj/2890 58396 article Soumya Satpathy 1 Sanat Kumar Bhuyan 2 Ruchi Bhuyan 1 Department of Medical Research, IMS and SUM Hospital, Siksha O Anusandhan Deemed to be University, Institute of Dental Sciences, SOA Deemed to be University, Bhubaneswar, Odisha, India Oral cancer was recognized as the most common type of cancer in South Asian countries including India. As concurrent chemoradiotherapy leads to various associated new problems, there is always a need for improved therapies without side effects. Natural plant products used since ancient times may fill the gap. Phytoconstituents can activate various cell death pathways, such as apoptosis, autophagy, or pyroptosis to treat oral tumors. Numerous studies have already been done to date to enlighten the detailed mechanism of the use of phytoconstituents in these cell-signaling pathways. As the majority of the studies emphasized the apoptotic pathway, the least reports are found on autophagy. ‘AMPK’  and ‘mTOR’ have been acknowledged to be the key signaling compounds that modulate autophagy. Therefore the objective of this article is to discuss the mechanism of autophagy concerning phytoconstituents in the treatment of oral carcinoma. https://biomedpharmajournal.org/vol17no2/targeting-autophagic-pathway-in-oral-cancer-therapy-through-phytoconstituents-a-short-review/ AMPK Autophagy mTOR Oral cancer Phytoconstituents