eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 1291 1300 10.13005/bpj/2942 59198 article Azizbek A. Abdullaev 1 Dolimjon R. Inamjanov 1 Dildora Sh. Abduazimova 1 Sirojiddin Z. Omonturdiyev 1 Ulugbek G. Gayibov 1 Sabina N. Gayibova 1 Laboratory of plant cytoprotectors of the Institute of Bioorganic chemistry named after academician A.S. Sadykov, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan This study delves into the crucial role of oxidative stress in non-infectious diseases and emphasizes the necessity of precise control over cellular oxidative processes using both natural and external antioxidant systems. Dysfunctions in these systems often result in various pathologies, underscoring the therapeutic promise of antioxidants in restoring cellular balance. Sílybum mariánum, known for its multifaceted biological properties such as antioxidative, hepatoprotector, anti - toxic, and organ-protective effects, emerges as a compelling subject for investigating its mechanisms, particularly in diabetes mellitus. Our research examines the impact of Sílybum mariánum's ethanolic extract on oxidative stress levels in alloxan-induced diabetic conditions. Our results demonstrate significant antioxidant effects of the extract on the heart and aorta preparations in diabetic rats. This study adds to the expanding body of research on the potential therapeutic utility of Sílybum mariánum in addressing oxidative stress-related complications linked with diabetes mellitus. https://biomedpharmajournal.org/vol17no2/silybum-marianums-impact-on-physiological-alterations-and-oxidative-stress-in-diabetic-rats/ Antioxidant system Alloxan Aorta smooth muscle Cellular oxidative process Diabetes mellitus Ethanolic extract Mechanism Oxidative stress