eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 1177 1185 10.13005/bpj/2932 59332 article Lipoprotein-Associated Phospholipase A2 and hs-CRP are Correlated with Anti-TPO Antibodies in Jordanian Non-Pregnant Women with Hashimoto’s Thyroiditis Mais Ahmad Alamro 1 Khaled A. Ahmed 1 Khaled M Khleifat 2 Belal 1 Usamah Sayed 1 Abdullah Saleh Al-wajeeh 3 Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan. Department of Medical Laboratory Sciences, Faculty of Science, Mutah University, Al-Karak 61710, Jordan. Anti-Doping Lab Qatar, Doha, Qatar. School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Hashimoto’s thyroiditis (HT) is an autoimmune disorder characterized by elevated thyroid-stimulating hormone (TSH) levels. This research investigates the complex interaction between HT and cardiovascular risk in adult Jordanian non-pregnant women aged 20-50. Through a study involving 50 HT subjects and 40 healthy subjects, the levels of lipoprotein-associated phospholipase A2 (PLA2), high sensitivity C-reactive protein (hs-CRP), and anti-thyroid peroxidase (anti-TPO) antibodies were compared using ELISA methods and enzymatic colorimetric assays for lipid profiles. The results revealed significantly higher serum levels of hs-CRP, PLA2, and Anti-TPO in Hashimoto's patients, coupled with elevated cholesterol, triglyceride, and low-density lipoprotein (LDL) levels. Conversely, reduced levels of high-density lipoprotein (HDL) were observed in Hashimoto’s patients compared to healthy subjects. The study establishes a noteworthy correlation between thyroid autoimmunity, thyroid disease, PLA2, hs-CRP, and lipid profile, underscoring an increased cardiovascular risk in individuals with Hashimoto’s thyroiditis. The findings emphasize the prevalence of Anti-TPO antibodies in adult Jordanian non-pregnant women with Hashimoto’s thyroiditis. https://biomedpharmajournal.org/vol17no2/lipoprotein-associated-phospholipase-a2-and-hs-crp-are-correlated-with-anti-tpo-antibodies-in-jordanian-non-pregnant-women-with-hashimotos-thyroiditis/ Anti-thyroid peroxidase Cholesterol C-reactive protein Hashimoto’s thyroiditis Thyroid-stimulating hormone