eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 757 767 10.13005/bpj/2902 58150 article Nirmala Ganesan 1 N. Anandhabhairavi 2 S. Arivarasan 3 V. Balamurugan 4 Anitha T Department of Biotechnology, School of Bioengineering Vels Institute of Science, Technology and Advanced Studies, Chennai, India. Department of Agricultural Entomology, School of Agriculture VELS Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India Department of Agricultural Economics, Agricultural College and Research Institute Madurai Tamil Nadu India. 4Department of Agricultural Economics, School of Agriculture VELS Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India Department of Postharvest Technology Horticultural College and Research Institute, Tamil Nadu Agricultural University, Periyakulam Tamil Nadu India. Liver plays a vital role in the elimination of xenobiotics that can induce hepatotoxicity in living organisms. Polymeric nanoparticles have evolved recently as an alternative in various industries and are used for their biomedical applications. Astragalin is a least studied flavonoid that has been used in the traditional medicine of Southeast Asia for its healing properties. Hence, in this study we used carbon tetrachloride as a hepatotoxin to induce liver damage. The protective effects of astragalin loaded polymeric nanoparticles on hepatotoxin-induced liver damage in experimental rats were assessed. The results of the assessment indicate that astragalin nanoparticles were effective in protecting the liver from damages induced by carbon tetrachloride. Astragalin nanoparticles formulation is not available in the market. Among existing literature, this is the first ever approach for hepatoprotective effect of astragalin nanoparticles studied. https://biomedpharmajournal.org/vol17no2/astragalin-nanoparticles-ameliorates-ccl4-induced-liver-fibrosis-in-rats/ Astragalin Carbon Tetrachloride Nanoparticles Hepatotoxicity PLA