eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-06-25 17 2 903 913 10.13005/bpj/2911 58754 article Amani Ali Shaman 1 Nahla S. Zidan 2 Sharifa Alzahrani 4 Laila A. AlBishi 5 Mohamed I. Sakran 6 Fahad M. Almutairi 6 Faculty of Medicine, , University of Tabuk, Tabuk, Kingdom of Saudi Arabia Faculty of science, food Science and Nutrition Dept, University of Tabuk, Tabuk, Saudi Arabia Department of Nutrition and Food Science Faculty of Specific Education,Kafrelsheikh University, Kafr El-Shaikh,Egypt Pharmacology Department, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia Pediatric Department, Faculty of Medicine,University of Tabuk, Tabuk,Saudi Arabia Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk,Saudi Arabia The effects of supplying experimental rats with  unicellular green algae Chlorella and tiny filamentous cyanobacteria Spirulina, on type 2 diabetes (T2DM) were examined in the present study. Eight sets of male Sprague-Dawley albino rats, each with six individuals, were used in the investigation. Throughout the trial, Group 1 was the negative control group and was given saline regularly. Group 2 was given alloxan to induce diabetes. Spirulina was given to groups 3, 4, and 5 at dosages of 100, 200, and 300 mg/kg body weight, respectively, after diabetes induction. Similarly, groups 6, 7, and 8 received dosages of 100, 200, and 300 mg/kg body weight of Chlorella, respectively. The findings indicated that the control group had significantly higher levels of triglycerides, low-density lipoprotein (LDL), blood sugar, and very low-density lipoprotein (VLDL) and considerably lower levels of insulin, high-density lipoprotein (HDL), and phospholipids. However, rats given Spirulina (groups 3, 4, and 5) showed notably higher insulin, HDL, and phospholipids levels and significantly lower blood glucose, cholesterol, VLDL, LDL, and triglycerides levels. Rats fed with Chlorella (groups 6, 7, and 8) also showed increased effectiveness of feed ratios, greater final weights, and body weight growth percentages compared to the control group. The present study shows that supplementing with Spirulina and Chlorella improves insulin lipid patterns, blood sugar, and type 2 diabetes in vivo laboratory rats. According to the research, Spirulina and Chlorella may be used as functional meals to help control and cure diabetes. https://biomedpharmajournal.org/vol17no2/anti-diabetic-activity-of-spirulina-and-chlorella-in-in-vivo-experimental-rats/ Antioxidants Chlorella Feed efficiency In vivo experimental rats Spirulina T2DM