eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2024-03-20 17 1 377 382 10.13005/bpj/2864 55613 article Shaik Aminabee 1 K. Ravi Shankar 2 KNV Chenchu Lakshmi 2 K. Saritha 2 R. Kavya 3 K. Chaitanya Babu 2 Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru-521356, Krishna District, A.P., India. KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Krishna District, A.P., India. QIS College of Pharmacy, Ongole, Prakasam District, A.P., India. Krishna University, College of Pharmaceutical Sciences and Research, Machilipatnam, Krishna District, A.P., India. This study depicts the selected dose of Allium sativum (104 mg/kg body weight) on the hypoglycemic activity of preferred dose of gliclazide which are studied in normal wistar rats. Materials required for the study are procured from Sai Chemicals, Visakhapatnam, India. Mature wistar rats of both the sex were used for the study. Prior to the trial the rats were confined for 18 hr with access to water ad libitum. During the study water was removed. Orally gliclazide was administered at 0.5 mg/kg, 1 mg/kg, 2 mg/kg body weight to I, II and III groups respectively. Blood samples are taken by retro-orbital puncture at intervals of 0, 1, 2, 3, 4, 6, 8, 10, 12 & 16 hr and blood glucose levels were determined by GOD/POD method. The acute dose of Allium sativum when given along with gliclazide  increased the hypoglycemic activity of gliclazide at 2^nd, 6^th and 8^th hr intervals but it was significant at 2^nd hr only and the effect was shown to be reduced at all other ie., 1^st, 3^rd, 10^th and 12^th hr time intervals. The aqueous extract of Allium sativum is influencing the absorption pattern of gliclazide since it was reported to have an increasing motility of the gastro intestinal tract. https://biomedpharmajournal.org/vol17no1/influence-of-allium-sativum-on-the-hypoglycaemic-activity-of-gliclazide-in-normal-rats-a-possible-approach-to-herb-drug-interaction/ Allium sativum Drug Interaction Gliclazide Hypoglycemic Activity