eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-12-31 16 4 2113 2121 10.13005/bpj/2786 53751 article Somaya Y. Shalaby 1 Mohamed A. Akela 2 Mustafa Karhib 3 Youssef Hussein 4 Mohamed Rabea 1 Ehab Tousson 5 Department of Zoology, Faculty of Science, Menoufia University, Egypt Department of Biology, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia Department of Medical Laboratory Techniques, Al-Mustaqbal University College, 51001 Hillah, Babylon, Iraq Departmentof Anatomy, Histology and Emberology, Faculty of Medicine, Mutah University, Al-Karak, Jordan Department of Zoology, Faculty of Science, Tanta University, Egypt A broad spectrum carbamate fungicide called carbendazim (Carb) that is very crucial for preventing plant diseases. and is one of the most pervasive environmental pollutants with serious implications for both human and animal health. In the current study, the role of Coriandrum sativum seeds extract (CSE) on carbendazim induced rats renal toxicity. Carb induced significant elevation in serum creatinine, urea, potassium, kidney malondialdehyde (MDA), nitric oxide (NO), renal injury, PCNA and significant depletion in serum sodium, calcium, renal glutathione (GSH). Treatments of Carb with CSE (CSE+Carb and/or Carb+CSE) improved these parameters and reduced renal toxicity with best results for Carb+CSE than CSE+Carb. Serum phosphorus revealed no significant changes between different groups. The above findings support the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb. https://biomedpharmajournal.org/vol16no4/prophylactic-effects-of-coriander-aqueous-extract-on-carbendazim-induced-renal-toxicity-in-male-rats/ Antioxidant Carbendazim Coriandrum sativum Kidney