eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-12-31 16 4 2491 2499 10.13005/bpj/2823 54218 article Amer Muayad Hussein 1 Ernez Hajri Samia2 2 Al-Snafi Ali Esmail 3 Ibn El Jazzar Faculty of Medicine, University of Sousse, Tunisia Department of Cardiology, Farhat Hached Hospital-Sousse, Ibn El Jazzar Faculty of Medicine, University of Sousse, Tunisia Department of Pharmacology, College of Medicine, University of Thi-Qar, Thi-Qar 64001, Iraq Coronary artery disease  (CAD)  is a significant cause of worldwide  mortality and morbidity. This study aims to evaluate the levels of serum H-FABP (fatty acid-binding protein), hs-CRP (high sensitivity- CPR),  Lp-PLA2 (lipoprotein PLA2), PCT (procalcitonin) and cytokines, in addition to routinely used diagnostic tests, Troponin I (Trop I), Myoglobin (MYO)  and Creatine kinase MB (CK-MB) in patients with stable angina to determine their sensitivity in diagnosing stable angina and  facilitating faster decision-making in the emergency unit. The current study was performed on 86 patients complaining  stable angina, at Nasiriyah Heart Center from October 2021 to October  2022.  Eighty-six, healthy subjects (age-matched) were taken as  a control group.   Blood samples were collected in the emergency department. Serum levels of hs CRP, H-FABP, CK-MB, Trop I, MYO, Lp-PLA2 and PCT were determined using electro-chemiluminescence immunoassay.  Blood sugar and serum total cholesterol, triglycerides, LDL, VLDL and HDL were determined using Cobas C311 photometric assays. Serum IL-6 was determined by using electro-chemiluminescence immunoassay, while,  IL-9, IL-1β and TNF-α were assayed by ELISA. The study showed that the level of troponin I didn’t  significantly change in patients with stable angina. However, compared with healthy controls, patients showed a significant increase in serum levels of  CK-MB, myoglobin, hs-CRP, H-FABP, Lp-PLA2 and PCT. Significantly elevated levels of serum  IL-6, IL1β, IL-9 and TNF-α  were also recorded in patients with stable angina compared to healthy controls. The results also revealed that patients with stable angina had significantly elevated serum levels of serum triglycerides, total cholesterol, LDL and VLDL with a significant decline of serum HDL compared to healthy controls. We can concluded that, in addition to cTnI, CK-MB and MYO, other biomarkers such as   hs-CRP, H-FABP, Lp-PLA2 and PCT are sensitive; and can serve as diagnostic indicators of stable angina pectoris for fast treatment. Furthermore, the detection of inflammatory biomarkers was found to be an additional diagnostic parameter in stable angina. https://biomedpharmajournal.org/vol16no4/diagnostic-value-of-crp-h-fabp-pct-lp-pla2-and-cytokines-in-stable-angina/ Biomarkers Cytokines Ischemic heart disease (IHD) Lipid profile Stable angina