eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-12-31 16 4 2419 2424 10.13005/bpj/2816 53334 article Sumit Kumar 1 Adithi K 2 Supriya P S 3 Shailaja S Moodithaya 3 Department of Physiology, KVG Medical College and Hospital (Affiliated to RGUHS), Sullia, Karnataka, India Department of Medicine, K.S Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India Department of Physiology, K.S Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India A plethora of research showed that vitamin D deficiency is one of the most prevalent dietary inadequacies in India. The condition is addressed as hypovitaminosis-D and often intervenes with the occurrence of diseases like cardio-metabolic disease. Though several epidemiological studies have supported this fact, there is an insufficiency of rational data to support the fact. Hence the current study investigates the relationship between vitamin D levels and markers of cardio-metabolic diseases among middle-aged adults. This study recruited  100 healthy middle-aged adults, and the participants underwent evaluation of their anthropometric measurements, Heart Rate Variability (HRV), and serum vitamin D levels. Analysis was done by taking consideration of total power (TP), absolute, and normalized power of high-frequency (HF), and low-frequency (LF) power spectrum including their ratio (LF/HF) as HRV indices. Data analysis was performed using the Pearson correlation test.  Data analysis showed a negative correlation between vitamin D and anthropometric measurements and a positive correlation with cardiac sympathovagal balance as determined by waist circumference and LF/HF ratio. However, there was no discernible correlation between vitamin D levels and the BMI, fat percentage, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), absolute power spectrum of HRV. The results of this study conclude that serum vitamin D levels affect central obesity and cardiac sympathovagal balance, indicating low levels of serum vitamin D might contribute higher risk for cardiovascular diseases. https://biomedpharmajournal.org/vol16no4/cardio-metabolic-indices-in-relation-to-serum-vitamin-d-levels-among-middle-aged-adults/ Fat percentage Heart rate variability Vitamin D Waist-hip ratio