eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-09-30 16 3 1837 1843 10.13005/bpj/2763 52124 article Fitim Alidema 1 Arieta Hasani Alidema 1 Albina Fejza 1 Albulena Jashari Selmani 2 UBT – Highger Institution – Fakulteti Farmacisë, Prishtinë, Kosovë Regional Hospital in Ferizaj- Prishtinë, Kosovo Introduction: Micronucleus test (MN) in buccal cells of the mouth presents a new road on the way of studying the degenerative changes directly in the targeted organs which were impacted by the tumoral diseases. Aim of the study: This paper aims to analyze the incidence of the test micronucleus in the epithelial cells of the buccal mucosa of the oral cavity in male patients with breast carcinoma after a cycle of chemotherapy. Material and Methods: In the study, 40 male patients with breast cancer with an average age of 45.8±15.5 years were taken for analysis. From the measured parameters, we analyzed the incidence of degenerative changes and the effect of chemotherapy, after one cycle of chemotherapy. Results: The average number of deteriorative modifications in the exfoliative cells deriving from the buccal mucosa of breast cancer patients, increased significantly after a single cycle of chemotherapy with 15.5±22.4 being the number of degenerated cells before treatments and 27.5±30.1 after the first cycle of chemotherapy, p<0.0002.  A significant increase was noticed in all types of nuclear degenerations. The incidence of acute nuclear changes as well as the total number of these modifications was high in males diagnosed with breast carcinoma Conclusion: The results show that cytostatic drugs induced cellular cytotoxicity. However, it did not significantly change chromosomal changes or the micronuclei formation. https://biomedpharmajournal.org/vol16no3/degenerative-changes-of-buccal-cells-after-one-cycle-of-chemotherapy-on-male-breast-cancer-patients/ Acute Nucleus Changes Breast Carcinoma Chemotherapy Incidence