eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-09-30 16 3 1451 1462 10.13005/bpj/2723 52173 article Saida S. Ncibi 1 Aymen, M. Madkhali 2 Magbool E. Oraiby 4 Jamilah A. Almalki 1 Hussein A. Khadashi 6 Abdullah A. Mobarki 5 Department of Biology, College of Science, Jazan University, KSA. Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University, Jazan, KSA. Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia. Poison control center Jazan, KSA. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia Substance Abuse and Toxicology Research center, Jazan University Artemisia judaica, Ruta graveolens, and Suaeda monoica, indigenous plants to Jazan, second smallest region of Saudi Arabia, have several uses in the local folk medicine. This research aims to study the chemical composition of their methanol extracts and to explore some related biological activities. The different extracts Gas Chromatography Mass Spectroscopy profiling revealed the occurrence of many compounds within these extracts. Besides, this study revealed varied and selective antibacterial activities of these extracts. Ruta graveolens methanol extract was effective in inhibiting the growth of all tested microorganisms. Furthermore, they exhibit an interesting cytotoxic effect on human breast cancer cell lines, especially Artemisia judaica methanol extract. These findings suggested that Artemisia judaica (Asteraceae), Ruta graveolens (Rutaceae), and Suaeda monoica (Chenopodiaceae) could be natural sources for the discovery of new drugs. https://biomedpharmajournal.org/vol16no3/antioxidant-antibacterial-and-cytotoxic-activities-of-artemisia-judaica-ruta-graveolens-and-suaeda-monoica-from-saudi-arabia/ Antibacterial Antioxidant Artemisia Judaica Cytotoxic Suaeda Monoica Ruta Graveolens