eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-09-30 16 3 1827 1835 10.13005/bpj/2762 51936 article Anwar M. M. Ezz 1 Somaia Zaki 1 Ghada A. Tabl 1 Faculty of Science, Zoology Department, Tanta University in Tanta, Egypt Department of Applied Chemistry ,College of Applied Science, University of Fallujah ,Iraq. Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq. Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with a few intricacies like hyperlipidemia. The current study aimed to study the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. A total of 70 male rats were divided into 7 groups (normal rats treated with the pomegranate peel extract and L-carnitine; rats given a high-fat diet to cause hyperlipidemia, this  rats given low-dose intraperitoneal streptozotocin injections to cause type II diabetes; diabetic rats given PPE and L-carnitine orally every day for 12 weeks. Measurements of body mass, blood sugar, lipid profile and antioxidant enzyme activity were made.Results: The treatment group that received PPE + L-carnitine showed a significant decrease in weight, blood glucose, cholesterol, triglycerides and low-density lipoprotein were significantly reduced, while high-density lipoprotein levels were significantly increased. Superoxide dismutase levels were increased, catalase and Nuclear Factor Erythroid-derived 2 (Nfe2) in diabetic rats treated with PPE and L-carnitine, while Malondialdehyde levels decreased significantly. According to the results of the study, PPE and L-carnitine  had significant anti-hyperglycemic, hypolipidemic, and antioxidant benefits after 12 weeks of treatment in streptozotocin-induced diabetic rats. https://biomedpharmajournal.org/vol16no3/anti-diabetic-effects-of-pomegranate-peel-extract-and-l-carnitine-on-streptozotocin-induced-diabetes-in-rats/ Diabetic Mellitus Pomegranate Peel Extract L-Carnitine