eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-03-21 16 1 113 117 10.13005/bpj/2593 47939 article Abdulrab Ahmed M. Alkhanjaf 1 Wala Eldin Osman Elradi 2 Abdel Rahim Mahmoud Muddathir 3 Ream Elzain Abdelgadir 4 Elharam Ibrahim Abdallah 2 Elhashimi E Hassan 5 Molecular Diagnostics, Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia. Department of Hematology and Blood Transfusion, Faculty of Medical Laboratory Sciences, Alzaeim Alazhari University, Khartoum, Sudan. Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Kingdom of Saudi Arabia. Hematology Department, Faculty of Medicine and Health Science- Kordofan University, Elobied- Sudan. Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia. Burkitt lymphoma, one of the two main types of B-cell non-Hodgkin lymphomas (B-NHL), is a cancer type that develops in the lymphatic system and is a very aggressive lymphoma. This study looked into the cytogenetic and molecular characteristics of Burkitt lymphoma in Sudanese individuals. Paraffin embedded tissue blocks associated to 34 people who had previously been diagnosed with burkitt's lymphoma and retained were studied as part of a retrospective cross-sectional study in Khartoum state, Sudan, in September 2017. The Soba Teaching Governmental Hospital and private histology laboratories provided these blocks. The analysis component included three translocations, including t(8;14) (q24;q32), t(8;22) (q24;q11), and t(2;8) (p12;q24) for 34 patients. We discovered that the majority of patients have t(8;14) (q24;q32), which was positive in 44.1% (15/34), while t(8;22) (q24;q11) verified in 17.6% (6/34) of patients. Only one (2.9%) displays a positive result for t(2; 8) (p12;q24). Although immune-phenotyping and morphological characteristics for BL were found in the study's 12 cases (35.3%), it is possible that these cases represent a different variety of  Burkitt's lymphoma caused by different forms of translocation. According to the study's findings, t(8;14) (q24;q32) remains the most common chromosomal rearrangement among Sudanese individuals with BL. Nevertheless, translocation of BL variations may exist, necessitating the use of advanced tools like sequencing, as these variants may play a significant role in the development and prognosis of disease. https://biomedpharmajournal.org/vol16no1/molecular-cytogenetic-characterization-of-burkitts-lymphoma-among-sudanese-patients/ BL: Burkitt’s lymphoma  Translocation