eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2023-03-21 16 1 251 263 10.13005/bpj/2607 48216 article Abduladeem G.M. Al-Selwi 1,2 Amina Barkat 3 Department: of Clinical epidemiology and medico-surgical sciences, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco Medical Research Laboratory, Children's Hospital, Ibn Sina University Hospital, Rabat, Morocco National Reference Center for Neonatology and Nutrition. Rabat Children's Hospital Ibn Sina, Rabat, Morocco Taiz University in Yemen Bacterial resistance to antibiotics has a very important role because it constitutes a threat to human health, especially immunocompromised people and children, this phenomenon can lead to difficulty or even the impossibility of treating certain infections. A meta-analysis from studies in Morocco on bacteria resistant to antibiotics over the last nine years and interest of bacterial: S. pneumoniae, N. meningitidis, H. influenzae and S. aureus, also the evolution their resistance. Total 654 articles in databases (206, 162, 134, and 152 articles found in: Elsevier, PubMed, Google Scholar, and other engines, respectively). For the bacteria in which we were interested, the prevalence of resistance increases with the years. Indeed, S. pneumoniae, N. meningitidis and H. influenzae, prevalence in 2012, 2016 and 2018 was respectively around (13%, 9.7%, 5.4%), (48%, 24%, 8%) and (29%, 33%, 8%). The evolution of the resistance of S. pneumoniae, was impacted by the introduction of the vaccine, indeed, the rate of its resistance to the antibiotic erythromycin before vaccination was 76% but after the introduction of the vaccine it decreased to 61%, while the incidence of pneumonia was 17.7%, and after vaccination it decreased to 10.2%. Also, the resistance of S. pneumoniae to penicillin G increased from 2.7% in 2011 to 100% in 2020. For N. meningitidis, resistance to penicillin G increased from 11.1% to 24% between 2012 and 2019. About of H. Influenzae for Bactrim, fluoroquinolones and tetracycline (16%, 4.8%, 2.5%), S.aureus resistance increases significantly. From 2016 to 2018, the resistance of S. aureus (Penicillin G 92%, ciprofloxacin 16.5%, erythromycin 14.6%). https://biomedpharmajournal.org/vol16no1/antibiotic-resistance-of-streptococcus-pneumoniae-neisseria-meningitidis-haemophilus-influenzae-and-staphylococcus-aureus-in-morocco-national-data-meta-analysis/ Antibiotics Bacteria resistance  Haemophilus influenzae Neisseria meningitidis  Streptococcus pneumoniae Staphylococcus aureus