eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-12-20 15 4 1837 1851 10.13005/bpj/2522 46728 article Walid Abu Rayyan 1 Waffaa Abu Hazzaa 1 Nesrin Seder 2 O'la Al-Fawares 1 Abdul Fattah Salah Fararjeh 1 Department of Medical Laboratory Analysis Faculty of Science, Al-Balqa Applied University, Al-salt, Jordan. Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan. Wuhan, China, substantially is the epicenter of the COVID-19 pandemic in December 2019. Coronavirus, the confounder virus, a zoonotic in origin was the causative agent of the disseminated disease worldwide. Structural similarities and convergence points were demonstrated between the coronavirus, SARS, and MERS viruses. Aberrantly, a subset of patients developed a serious acute respiratory distress syndrome or diffuse alveolar injury whereas the rest of the patients encountered mild or no symptoms. The pathological clinical laboratory findings are not only critical in the diagnosis of the COVID-19 infection, on the contrary, but they are also crucial in the prognostic predictions about disease prognosis and therapeutic response. This review aims to give some historical context for the pandemic, demonstrate the laboratory's important role in the screening of COVID-19 infection, and review the current phase of biomarker examination in COVID-19 infection, focusing on markers derived directly from the hematological laboratory, reflecting the implications of COVID-19 on the hematological system and coagulation pathways. In conclusion, there is a direct significant correlation between infection severity, the death rate in COVID-19 patients, and the low number of either WBCs or a high number of WBCs with a low number of lymphocytes. https://biomedpharmajournal.org/vol15no4/the-implications-of-covid-19-infection-on-hematologic-parameters-and-coagulation-activity-a-systematic-review/ COVID-19   Coagulation D-Dimer Hematology  Lymphopenia