eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-12-20 15 4 2209 2216 10.13005/bpj/2558 46704 article Syahrida Dian Ardhany 1 Susi Novaryatiin 1 Guntur Satrio Pratomo 2 Department of Pharmacy Faculty of Health Sciences, Muhammadiyah University of Palangkaraya, Palangka Raya, 73111 Bawi Bakena Tuntung Bahalap Industry, Palangka Raya, 73111 Several studies revealed that the ethanolic extract, cream, and loose powder of Bawang Dayak bulbs (Eleutherine bulbosa (Mill.) Urb.) are effective in inhibiting the growth of different acne-causing bacteria, including S. aureus, S. epidermidis, and P. acne. Several product series have also been developed using the plant for the treatment of acne-prone skin. Therefore, this study aims to carry out a primary irritation test of E. bulbosa loose powder using the patch test method on rabbits and humans to determine its safety before it is marketed. The results showed that the primary irritation index of E.bulbosa loose powder on rabbits was 0.125, which was classified in the negligible category, and there were no signs of erythema or edema in humans. This indicates that it does not cause irritation and has the potential to be developed into anti-acne products. https://biomedpharmajournal.org/vol15no4/irritation-test-of-bawang-dayak-eleutherine-bulbosa-mill-urb-loose-powder-for-acne-vulgaris/ Acne Bawang Dayak  Eleutherine bulbosa  Patch Test