eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-12-20 15 4 1797 1819 10.13005/bpj/2519 46746 article Abdel-Nasser El-Shorbagi 2 Sachin Chaudhary 1 Anurag Chaudhary 3 Garima Agarwal 3 Prabhash Nath Tripathi 3 Shweta Dumoga 3 Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates, Faculty of Pharmacy, University of Assiut, Assiut, Egypt Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, NH-58, Baghpat Road Crossing, Bypass Road, Meerut, Uttar Pradesh, India β-lactam antibiotics are considered the safest bactericides, and upon wide clinical use of benzyl penicillin G in 1945, outbreaks of resistance came out. The frequent semi-synthetic strategies revealed β-lactam generations that are of broad-spectrum activity. The new agents as well as their concomitant use with known inhibitors of β-lactamases potentiate their effectiveness versus higher numbers of resistant pathogens. However, the extremely resistant pathogens are still representing a burden. Efforts had been continued to find more inhibitors of β-lactamases to combine with β-lactams to provide good management of infections by extremely resistant microbes. The purpose of this work is to overview the conventional and the recently introduced β-lactamases in clinical applications, as well as some reported effective inhibitors of β-lactamases. The review pinpoints the inhibitors that can be mixed and/or merged with the beta-lactam antibiotics to effectively treat the microbial infections producing resistant-β-lactamases. ClogP for these drugs and candidate inhibitors is introduced as suggestions to open a door for developers to admix derivatives with suitable pharmacokinetics. https://biomedpharmajournal.org/vol15no4/beta-lactamases-inhibitors-a-perspective-on-the-existing-and-the-potential-admixtures-to-synergize-beta-lactams-versus-resistant-superbugs/ Antibacterial  β-lactamases inhibitors Clinical investigations  Multi-resistant strains