eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1427 1436 10.13005/bpj/2480 45362 article Nicolás Padilla-Raygoza 1 Efraín Navarro-Olivos 2 María de Jesús Gallardo-Luna 1 Gilberto Flores-Vargas 1 María del Rosario Sanchez-Navarro 3 Elia Lara –Lona 4 Department of Research and Technological Development, Directorate of Teaching and Research, Institute of Public Health from Guanajuato State, Guanajuato, México Directorate of Teaching and Research, Institute of Public Health from Guanajuato State, Guanajuato, México Secretary of Health form Guanajuato State, Mexico Department of Medicine and Nutrition, Division of Health Sciences, Campus Leon, University of Guanajuato, Leon, Mexico Service of Immunology and Allergy, Hospital of Pediatrics Specialties from Leon, Institute of Public Health from Guanajuato State, León, Mexico Directorate of Health Services, Institute of Public Health from Guanajuato State, Guanajuato, Guanajuato México Background. Guanajuato state in Mexico has high frequency of confirmed cases of COVID-19. Health-care workers are the most exposed to contagion due to contact with patients infected by SARS-CoV-2. The objective was to know the seroprevalence of antibodies (IgG) anti-SARS-CoV-2 in health-care workers from Secretary of Health from Guanajuato State. Material and methods. It was a cross-sectional, retrolective study, using database from the ENSERO-COVID program. It was recollected data about exposure in work and in community by contact with confirmed cases of COVID-19. The anti-SARS-CoV IgG antibody titer was determined, considering 1.4 or higher as positive. It used Chi squared test to show relationship between variables, Z for two proportions to test hypotheses and logistic regression for show the effect of exposure and test positive for antibodies. Results. 4,047 registries were reviewed, 376 (9.29%) were positive for the presence of SARS-CoV-2 antibodies. There is an association between the type of work unit (type determined by hospitalizing COVID-19 patients or not) with seropositivity (P <0.05). There was no effect of performance areas to be seropositive. Community exposure had an effect on being seropositive OR = 1.44 (1.17 - 1.79). Training in the proper use of personal protective equipment had a protective effect on being seropositive with OR = 0.79 (0.64 -0.99). Conclusion. Exposure in the community to a confirmed case to SARS-CoV-2 is found to have a significant association with the presence of anti-SARS-CoV-2 antibodies. Training in the proper use of personal protection equipment is a protector against SARS-CoV-2 infection. There is a significant association between the type of unit and the presence of anti-SARS-CoV-2 antibodies. Given the increase in the number of confirmed cases of SARS-CoV-2, it is vitally important that health workers adequately protect themselves both at the community and workplace level. https://biomedpharmajournal.org/vol15no3/seroprevalence-of-sars-cov-2-in-health-care-personnel-from-the-state-of-guanajuato-mexico-a-cross-sectional-study/ Antibodies COVID-19 Infection population SARS-CoV-2