eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1271 1275 10.13005/bpj/2463 45577 article Anak Agung Gede Budhitresna 1 Dewa Putu Surawan 3 Ratna Kartikadewi 1 Adi Harta Yoga 1 Putri Permana Lestari 1 Nyoman Trisna Sumadewi1 1 Sri Masyeni 3 Antigen tests to screen coronavirus disease 2019 (COVID-19) is effective in symptomatic patients, leading to its wide usage in informing whether the person is COVID-19 positive or negative. Our current work had an objective to investigate the diagnostic performance of two antigen-detecting rapid diagnostic tests (Ag-RDTs) which are commonly used in Indonesia. A cross-sectional study was carried out to compare specificity, sensitivity, as well as expected predictive values of Anhui Ag-RDT and Lungene Ag-RDT by comparing the results with that obtained from real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. A total of 98samples were tested for both Ag-RDTs and RT-PCR. The median value of the patients age obtained to be 41.78 years old (interquartile range: 1 to 91 years old). The proportion between female and males was: 52.53% vs 47.47%. The sensitivities of Anhui Ag-RDT and Lungene Ag-RDT were 55.56% and 51.58%, where both Ag-RDTs had specificity of 100%. In conclusion, sensitivity values of Lungene Ag-RDT and Anhui Ag-RDT are similar, where both possess 100% specificity with zero false-positive results. Both of the investigated Ag-RDTs are useful since positive results are likely to be COVID-19 positive. https://biomedpharmajournal.org/vol15no3/performance-of-two-rapid-antigen-detection-tests-for-detecting-covid-19-compared-to-rt-pcr-in-indonesia/ COVID-19  Ct value  Diagnostic Performance  Rapid Antigen Test  RT-PCR