eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1453 1467 10.13005/bpj/2483 45718 article Mohamed G Hamed 1 Abdelmonem Awad Hegazy 2 Ahmed Embaby 1 Shimaa Abdelmoneem 1 Amany Abd Al Badea 3 Ali Awad 3 Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt, Medical Lab Department, Faculty of Allied Medical Sciences, Zarqa University, Jordan, Otorhinolaryngology Department, Faculty of medicine, University, Egypt, Chest Medicine Department. Faculty of Medicine Zagazig University, Egypt, Pathology Department, Faculty of Medicine, Zagazig University, Egypt, Family Medicine Fellowship in the Egyptian MOHP, Egypt, Background: Coronavirus disease 2019 (COVID-19) may lead to immunosuppression, leaving patients vulnerable to secondary invasive fungal infection like mucormycosis. The present study aimed to determine whether there are any risk factors associated with mortality in mucormycosis among COVID-19 patients. Patients and Methods: Patients with COVID-19 diagnosed with mucormycosis who received treatment at University Hospitals were included in the study. Complete blood count (CBC), glycated hemoglobin (HBA1c), C-reactive protein (CRP), serum albumin level, creatinine, ferritin levels, lactate dehydrogenase (LDH), D-dimer and histopathological observations were performed for all participants’ specimens. Results: The number (N) of patients included in the study was 46. About 85 % (39/46) of patients had post-COVID-19 syndrome and the other 7 cases were in the active phase of the disease. CRP, serum ferritin, D-dimer, CRP/albumin ratio and CRP/absolute lymphocyte counts were statistically significant (P<0.05) within non-survivors as compared to survivors. After analysis of multivariate analysis that patients had oxygen support, while elevated CRP/albumin ratios were independent predictors of mortality in COVID-19 patients associated with mucormycosis. Conclusions: Mucormycosis can be caused by immunosuppression conditions associated with COVID-19 infection. Oxygen levels and C-reactive protein/albumin are independent predictors of mortality and morbidity in post COVID-19 patients. https://biomedpharmajournal.org/vol15no3/identifying-independent-predictors-of-mortality-in-covid-19-patients-with-mucormycosis/ Mucormycosis Outcome predictors Prognostic markers  SARS-CoV-2