eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1497 1502 10.13005/bpj/2487 45874 article Wa Ode Nova Noviyanti Rachman 1 Muhammad Syafar 1 Sudirman Nasir 1 Ridwan Amiruddin 1 Abdul Kadir Ahmad 2 Muhamad Tahir Abdullah 1 Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi National Research and Innovation Agency, Indonesia Faculty of health sciences, University Mandala Waluya, Southeast Sulawesi Narcotics, Psychotropics, and Other Addictive Substances (also called drugs) are the substances that affect the structure or function of several body parts of people who consume them, including adolescents. The increase in drug use in adolescents continues to increase by 24-28%. This study aimed to analyze the effect of the drug abuse behavior prevention model by using a module with a juvenile family approach in Kendari City. This study was a sequential exploratory mixed method. There were 5 people for in-depth interviews, and 10 people for FGD. The sample size was 132 people, consisting of 66 respondents for the intervention group, and 66 respondents for the control group. In analyzing the qualitative data, the researcher used content analysis, while quantitative data used a pretest-posttest group control design with a non-parametric test. The results of this study showed that 1) the informants were lack of knowledge about drugs, 2) drugs could ruin a teenager's future, 3) National Narcotics Agency has carried out drugs socialization, 4) the informants were worried and afraid of drugs trafficking, 5) the informants did not dare to report drugs abuse, 6) the informants prohibited teenagers to not hanging out with strangers, 7) the role of the village head was very much needed by the community, 8) staying away from drugs, and 9) the role of parents at home was very much needed by adolescents. Giving the module to the intervention group before and after the intervention showed that the level of knowledge and attitudes of parents increased with a p-value of 0.000. Therefore, this study concluded that there was an effect of the intervention model for preventing drug abuse behavior by using a family approach module, there was an effect of drugs abuse behavior prevention model using a module on family knowledge, and there was an effect of drugs abuse behavior prevention model using a module on family attitudes. https://biomedpharmajournal.org/vol15no3/drugs-abuse-behavior-prevention-model-through-family-approach-in-adolescents-in-kendari-city/ Adolescents  Drugs Abuse Prevention  Family Approach Module