eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1519 1527 10.13005/bpj/2490 45222 article Neha Daniel George 1 Sonal Bhat 1 Sunil B. V 1 Department of Anaesthesiology, Kasturba Medical College, Mangaluru, Manipal Academy of Higher Education, Manipal India. Background : Analgesia post knee arthroplasties are crucial in early postoperative recovery and discharge . The objective of this study was to compare the analgesic efficacy of Adductor canal block with that of femoral nerve block in patients undergoing knee arthroplasties. Methods : 140 participants aged 18 years & above under American Society of Anaesthesiologists 1 and 2 physical status undergoing knee arthroplasty under spinal anaesthesia were included and  were divided into 2 groups – Adductor canal block and femoral nerve block who were administered blocks under ultrasound guidance. The preoperative Visual Analog Scale score, haemodynamic variables and postoperative Visual Analog Scale scores were recorded. Results : The Visual Analog Scale scores between the two groups were not statistically significant however, a significant difference in the time taken by the Adductor canal block participants to request analgesia and to ambulate. Conclusion: Adductor canal block with Dexmedetomidine was equally efficacious when compared to Femoral nerve block  with Dexmedetomidine in patients undergoing Total knee arthroplasty. https://biomedpharmajournal.org/vol15no3/comparison-of-femoral-nerve-block-with-dexmedetomidine-and-adductor-canal-block-with-dexmedetomidine-for-postoperative-analgesia-for-total-knee-arthroplasty/ Dexmedetomidine Femoral nerve block  Postop Analgesia  Total Knee Arthroplasty  Ultrasonography guided nerve blocks Adductor canal block