eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1477 1482 10.13005/bpj/2485 45643 article Hind Amin Ishaq 1 Mariam Abbas Ibrahim 1 Amar Mohammed Ismail 2 Nuha Eljaili Abubaker 1 Elyasa M Elfaki 3 Department of Clinical Chemistry, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, AL-Neelain University, Sudan 3Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Al-Qurayyat, Saudi Arabia Background: Pathogenesis of type 1 diabetes mellitus is associated with the presence of specific autoantibodies and viral infection. Herein we aim to assess specific and nonspecific autoantibodies in newly diagnosed type 1 diabetes mellitus patients. Materials and Methods: In this case-control study 200 subjects were enrolled, classified into 100 newly diagnosed type 1 diabetes mellitus patients ages ranged from 1 to 16 years old, and 100 apparently health control age matched group. Serum anti-glutamic acid decarboxylase/tyrosine Phosphatase 2 (anti-GAD/IA2), anti-tissue transglutaminase (anti-tTG) and antinuclear antibodies were measured. Results:  Of 100, 62(62%) were males, and 38(38%) were females. Anti-GAD/IA2, anti-tTG, and antinuclear antibodies were found to be significantly higher in the case than in the control group. Anti-GAD/IA2 and anti-tTG were associated with higher risk of type 1 diabetes mellitus (OR= 5.44, P= 0.000) and (OR=5.82, P= 0.009) respectively. Conclusion: Anti-GAD/IA2, anti-tTG and antinuclear antibodies are higher in type 1 diabetes mellitus patients. Moreover, anti-GAD/IA2 and anti-tTG are associated with a high risk of type 1 diabetes mellitus. https://biomedpharmajournal.org/vol15no3/assessment-of-specific-and-non-specific-autoantibodies-among-newly-diagnosed-type-1-diabetes-mellitus-sudanese-patients/ ANAs Anti-tTG  Anti-GAD/IA2 Celiac Disease  Type-1 DM