eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1647 1651 10.13005/bpj/2502 45394 article I Gusti Agung Ayu Dharmawati 1 Nur Habibah 1 I Gusti Agung Ayu Putu Swastini 1 Heri Setiyo Bekti 2 Medical Laboratory Technologist, Polytechnic of Health Denpasar, Bali, Indonesia Center of Excelence in Science and Technology, Polytechnic of Health Denpasar, Bali, Indonesia, Wild mango (Spondias pinnata (L.f) kurz) or Cemcem or Kecemcem is one of the famous plants in Bali. It is widely used by Balinese as both food and traditional medicine. Several study has shown that S. pinnata leaf extract has antibacterial activity against several Gram-positive and Gram-negative bacteria. S. mutans is a Gram-positive bacteria that causes dental caries. In Indonesia, the prevalence of dental caries is 88.8% and most suffered by toddlers. The purpose of this study was to determine the effect of ethanol extract of S. pinnata leaves in inhibiting the growth of S. mutans. Inhibition zone test was carried out using the diffuse disc method with two extract concentrations of 60% and 80%, respectively. From the results, it was found that the inhibition zone of 60% concentration was 12.95 mm and 80% concentration was 15.77 mm. Both fall into the category of strong inhibition zones. Based on this, the ethanol extract of S. pinnata leaves can be used as a natural antibacterial agent. https://biomedpharmajournal.org/vol15no3/antibacterial-potential-of-spondias-pinnata-l-f-kurz-leaf-ethanol-extract-against-streptococcus-mutans-bacterial-growth/ Antibacterial Activity Ethanol Extract Spondias pinnata Streptococcus mutans