eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-09-29 15 3 1687 1693 10.13005/bpj/2507 45463 article Jargalsaikhan Gombodorj 1 Enkhjargal Bayarsaikhan 3 Chimedragchaa Chimedtseren 2 Uuganbayar Baatartsogt 2 Baigali Gansukh 2 Seesregdorj Surenjid 1 International School of Mongolian Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia Institute of Traditional Medicine and Technology, Ulaanbaatar, Mongolia National cancer center of Mongolia, Ulaanbaatar, Mongolia Objectives: To investigate the anti-inflammatory activity of Khurtsiin deed-6 in migraine and neurodegeneration rat models. Methods: This study uses nitroglycerin induced migraine was model and alcohol exposed neurodegeneration model in Wistar rats to evaluate anti-inflammatory effect of Khurtsiin deed-6 at the 3 different doses of 50, 100and 150 mg/kg, orally. After anesthesia, the brains were removed, then trigeminal nucleus caudal is and hippocampus region isolated from fresh brain. And followed by protein and RNA extraction. Interleukin-1β expression was analyzed by real time polymerase chain reaction. Results: Nitroglycerin induced rat migraine model had increased Interleukin-1β expression in brain TNC area (p<0.001). It has been decreased dramatically after treatment of Khurtsiin deed-6 by doses of 50mg/kg, 100mg/kg and 150mg/kg treatment in brain trigeminal nucleus caudal is region (p<0.01) comparing ibuprofen treated group. Moreover alcohol exposed neurodegeneration rat model had observed increased Interleukin-1β expression in brain Hp area (p<0.001). But Khurtsiin deed-6 doses of 50mg/kg, 100mg/kg and 150mg/kg treatment reduced neuroinflammatory cytokines IL1β expression in hippocampus region (p<0.01, p<0.001) of alcoholic rat models comparing pyridoxamine administrated animals. Conclusion: The present finding indicates that Khurtsiin deed-6shows anti-inflammatory activity decreasing the level of Interleukin -1β cytokine in nitroglycerin induced migraine and alcohol exposed neurodegeneration rat models https://biomedpharmajournal.org/vol15no3/an-analysis-of-khurtsiin-deed-6-compounds-effect-on-il-1%ce%b2-expression-in-nitroglycerin-induced-migraine-and-alcohol-exposed-neurodegeneration-model-in-rat/ Hippocampus Region  Interleukin 1β  Khurtsiin deed-6  Migraine Neurodegeneration  Nucleus Caudalis  Trigeminal