eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-06-30 15 2 643 650 10.13005/bpj/2403 43982 article Heggadadevanakote Kendaganna Pavan 1 Govindaraju Shruthi 2 Kollur Shiva Prasad 3 Sharanagouda S Patil 4 Chandan Shivamallu 1 Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysore, Karnataka, India. Glimetomics Bioresolve Pvt Ltd, Mysuru, Karnataka-570 018, India. Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru – 570 026, Karnataka, India. ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India Antibiotics are commonly used to treat bacterial respiratory infections, but they can exacerbate inflammation by releasing microbial components that overstimulate the immune system, leading to greater tissue damage. Klebsiella pneumoniae is a gram-negative, rod-shaped bacteria of the family Enterobacteriaceae. Knowing about Klebsiella pneumoniae is extremely important in the present situation, as it is one of the major causal organisms of pneumonia. Internal and external factors of K. pneumoniae are responsible for the entry and multiplication inside the host. Antibiotics against K. pneumoniae are a class of Penicillins, Cephalosporins, Monobactams, and Carbapenems which have the β-lactam ring in common with variable side chains. Combating the antibiotics by synthesizing the enzymes like beta-lactamases is the main reason for the survival of these organisms against newer generation antibiotics. In this review, we have tried to discuss about Klebsiella pneumoniae, antibiotics, and their mechanism of action. https://biomedpharmajournal.org/vol15no2/review-of-known-and-unknown-facts-of-klebsiella-pneumoniae-and-its-relationship-with-antibiotics/ Beta-Lactamases  Biofilm  Klebsiella pneumoniae  Monobactam Penicillin