eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-06-30 15 2 1109 1113 10.13005/bpj/2446 44395 article Em Sutrisna 1 Devi Usdiana 1 Sri Wahyuni 1 Medical faculty of Universitas Muhammadiyah Surakarta, Indonesia The number of herbal medicines in Indonesia as cholesterol drugs is still lacking. Guazuma ulmifolia Lamk. is one of the plants suspected of having an anticholesterol effect. The test design is pre and post test with control group design. A total of 30 rats were divided into 5 groups, with each group consisting of 6 rats. Aquadest as a negative control group and simvastatin 0.72mg/200 bw orally is a positive control group. Groups III, IV, and V were treated the test extract with 3 dose levels. A mouse model of hyperlipidemia was performed with Triton-X. Treatment was carried out for 7 days and cholesterol is measured. Liver organs was taken for histopathological examination. The ethanolic extract of the ethyl acetate fraction of Guazuma ulmifolia Lamk was able to reduce total cholesterol in rats induced by a high cholesterol diet. From the histopathological examination, the ethanol extract of the ethyl acetate fraction of Guazuma ulmifolia Lamk improved liver histoPA. The ethanolic extract of the ethyl acetate fraction of Guazuma ulmifolia Lamk has potencies to develop as hypocholesterolemia agent. https://biomedpharmajournal.org/vol15no2/hypocholesterolemia-effect-of-guazuma-ulmifolia-lamk-on-rats-model-hyperlipidemic-and-liver-histopathological-picture/ Guazuma ulmifolia Lamk Herbal Medicine  hypocholesterolemia Agent