eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-06-30 15 2 891 895 10.13005/bpj/2423 44571 article Khilola A. Rakhmanova 1 Sherzod N. Zhurakulov 2 Firuza M. Tursunkhodjayeva 1 Azizbek A. Azamatov 1 Dilfuza M. Saidkhodjayeva 1 Inoyat Z. Jumayev 3 It is known that natural isoquinoline alkaloids are widely used in pharmacology and have a variety of biological activities¹. At the same time, synthetic analogs of isoquinoline alkaloids are of great interest, among which compounds have been identified that are promising agents that modulate the activity of the dopamine and serotonergic systems^2,3, showing cardiprotective⁴ effect, antiproliferative⁵ and analgesic⁶ activity. Currently, in practical medicine, aspirin and anlagen are widely used as non-narcotic analgesics⁷. However, the low intensity of the analgesic effect, the lack of an analgesic effect in certain types of pain (thermal, mechanical, and other acute pain) and the large number of side effects caused by long-term use limits the scope of their application. The properties of 1-(4’-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) have not been previously described in the scientific literature. The analgesic and anti-inflammatory activity of 1-(4'-dimethylaminophenyl)-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) was studied under conditions of thermal (hot plate test) and chemical (vinegar writhing test) irritation, anti-inflammatory activity - on the model of acute inflammatory arthritis. As a result of the studies, it was found that the compound 1-(4'-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline in various doses has an analgesic and anti-inflammatory effect. 1-(4'-Dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) showed a pronounced anti-inflammatory effect at a dose of 0.5 mg/kg, 3.3 times greater than the effect of diclofenac sodium. It has been shown that 1-(4’-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (3) has a pronounced analgesic and anti-inflammatory activity and can be used in medical practice as a non-narcotic analgesic. https://biomedpharmajournal.org/vol15no2/analgesic-and-anti-inflammatory-effects-of-1-4-dimethylaminophenyl-6-7-dimethoxy-1234-tetrahydroisoquinoline-hydrochloride/ Acute Toxicity Analgesic and Anti-Inflammatory Activity  Acetylsalicylic Acid  Diclofenac Sodium  Tetrahydroisoquinoline Hydrochloride  metamizole sodium