eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-06-30 15 2 563 578 10.13005/bpj/2397 43984 article Ramesh Kumar Gupta 1 Sachin Chaudhary 2 Abdel-Nasser El-Shorbagi 2 Udaivir Singh Sara 3 Prashant Shukla 3 Sudhansu Ranjan Swain 4 Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research Lucknow, Uttar Pradesh, India 2Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research Lucknow, Uttar Pradesh, India Department of Pharmacognosy, Moradabad Educational Trust Group of Institutions, Faculty of Pharmacy, Moradabad, Uttar Pradesh, India Department of Pharmaceutics, School pf Pharmaceutical and Population Health Information, Dehradun Institute of Technology University, Dehradun, Uttarakhand, India Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur 760 002, Orissa, India At this moment, liver dysfunction is a major source of destruction, and its widespreadity is accentuated in the developed republics. The liver is an imperative organ of the body and is involved in metabolism and regulation. The large number of medications, toxins, and plant-derived products has been claimed to cause liver dysfunction, which is potentially life intimidating to humans. Currently, there is a shortfall in encouraging treatment for treating patients with liver dysfunction due to the nonexistence of empathy for gesturing offenders serviceable in the pathogenesis of liver toxicity. Hepatic dysfunction is manifested by hepatic karyopyknotic, eosinophilic or acidophilic cell plasm, followed by excessive steatosis, liver injury, and oxidative degradation of lipids that cause centrilobular necrosis in hepatocytes. Different signaling mechanism, like activation of Kupffer cells, NK cells, inflammatory mediators, and ROS are associated with the pathogenesis of liver dysfunction. A good empathy of chief mechanisms is prerequisite for the scheming of novel curative medications. Consequently, animal models are being developed to impressionist hepatic ailments. From the several decades, researchers are using distinctive animal models for discovering and understanding pathogenesis of hepatic ailments and associated abusiveness. This current review has been framed to discuss numerous new and traditional experimental models for hepatotoxicity studies. Numerous animal models have been evolved to evaluate the pathogenesis and develop drugs for hepatotoxicity. Experimental modes of hepatotoxicity are influential for invention of novel molecular signaling trails for the improvement of human health. https://biomedpharmajournal.org/vol15no2/a-comprehensive-review-of-experimental-animal-models-of-hepatopathy/ Animal model  Hepatotoxicity Hepatocytes  Kupffer cell  Necrosis  Pathogenesis